MCBO / Publications
Vogel G, Janecke A, Krainer I, Gutleben K, Witting B, Mitton S, Mansour S, Ballauff A, Roland J, Engevik A, Cutz E, Müller T, Goldenring J, Huber L, Hess M
Abnormal Rab11-Rab8-vesicles cluster in enterocytes of patients with Microvillus Inclusion Disease
Traffic. 2017 Apr 13. doi: 10.1111/tra.12486. [Epub ahead of print]

Schenk R, Tuzlak S, Carrington E, Zhan Y, Heinzel S, Teh C, Gray D, Tai L, Lew A, Villunger A, Strasser A, Herold M
Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment
Cell Death Differ. 2017 Mar;24(3):534-545. doi: 10.1038/cdd.2016.156. Epub 2017 Jan 13.

Janecke A, Xu R, Steichen-Gersdorf E, Waldegger S, Entenmann A, Giner T, Krainer I, Huber L, Hess M, Frishberg Y, Barash H, Tzur S, Schreyer-Shafir N, Sukenik-Halevy R, Zehavi T, Raas-Rothschild A, Mao C, Müller T
Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications
Hum Mutat. 2017 Apr;38(4):365-372. doi: 10.1002/humu.23192. Epub 2017 Mar 6.

Culig Z, Puhr M
Interleukin-6 and prostate cancer: Current developments and unsolved questions
Mol Cell Endocrinol. 2017 Mar 16. pii: S0303-7207(17)30181-8. doi: 10.1016/j.mce.2017.03.012. [Epub

Mastrolia V, Flucher S, Obermair G, Drach M, Hofer H, Renström E, Schwartz A, Striessnig J, Flucher B, Tuluc P
Loss of α2δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes
Diabetes. 2017 Jan 23. pii: db151349. doi: 10.2337/db16-0336. [Epub ahead of print]

Charoentong P, Finotello F, Angelova M, Mayer C, Efremova M, Rieder D, Hackl H, Trajanoski Z
Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
Cell Rep. 2017 Jan 3;18(1):248-262. doi: 10.1016/j.celrep.2016.12.019.

Campiglio M, Flucher B
STAC3 stably interacts through its C1 domain with CaV1.1 in skeletal muscle triads
Sci Rep. 2017 Jan 23;7:41003. doi: 10.1038/srep41003.

Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf C, Pope L, Rossen N, Flucher B, DeGrado W, Minor DL Jr.
Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS Chem Neurosci. 2017 Mar 17. doi: 10.1021/acschemneuro.6b00454. [Epub ahead of print]

Tuzlak S, Schenk R, Vasanthakumar A, Preston S, Haschka M, Zotos D, Kallies A, Strasser A, Villunger A, Herold M
The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection
Cell Death Differ. 2017 Mar;24(3):523-533. doi: 10.1038/cdd.2016.155. Epub 2017 Jan 13.

Fava L, Schuler F, Sladky V, Haschka M, Soratroi C, Eiterer L, Demetz E, Weiss G, Geley S, Nigg E, Villunger A
The PIDDosome activates p53 in response to supernumerary centrosomes
Genes Dev. 2017 Jan 1;31(1):34-45. doi: 10.1101/gad.289728.116.

Pichler R, Fritz J, Heidegger I, Steiner E, Culig Z, Klocker H, Fuchs D
The predictive and prognostic role of serum neopterin and tryptophan breakdown in prostate cancer.
Cancer Sci. 2017 Jan 20. doi: 10.1111/cas.13171. [Epub ahead of print]

Rzhepetskyy Y, Lazniewska J, Proft J, Campiglio M, Flucher B, Weiss N
A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane
Channels (Austin). 2016 Sep 2;10(5):346-354. Epub 2016 May 5

Boltengagen M, Huang A, Boltengagen A, Trixl L, Lindner H, Kremser L, Offterdinger M, Lusser A
A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster.
Nucleic Acids Res. 2016 Mar 18;44(5):2145-59.

Klepsch-Pedit V, Hermann-Kleiter N, Baier G
Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy.
Immunol Lett. 2016 Oct;178:31-6. doi: 10.1016/j.imlet.2016.03.007. Epub 2016 Mar 15.

Pinggera A, Striessnig J
Cav 1.3 (CACNA1D) L-type Ca2+ channel dysfunction in CNS disorders.
J Physiol. 2016 Feb 4. doi: 10.1113/JP270672.

Schafferer S, Khurana R, Refolo V, Venezia S, Sturm E, Piatti P, Hechenberger C, Hackl H, Kessler R, Willi M, Gstir R, Krogsdam A, Lusser A, Poewe W, Wenning G, Hüttenhofer A, Stefanova N
Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications
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Khalid S, Drasche A, Thurner M, Hermann M, Ashraf M, Fresser F, Baier G, Kremser L, Lindner H, Troppmair J
cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.
Sci Rep. 2016 Feb 12;6:20930. doi: 10.1038/srep20930. PubMed PMID: 26868434; PubMed Central PMCID: P

Sochalska M, Ottina E, Tuzlak S, Herzog S, Herold M, Villunger A
Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Cell Death Differ. 2016 Apr;23(4):628-39. doi: 10.1038/cdd.2015.130. PubMed PMID: 26450454; PubMed C

Pfeiffenberger E, Sigl R, Geley S
Conditional RNAi Using the Lentiviral GLTR System.
Methods Mol Biol. 2016;1448:121-38. doi: 10.1007/978-1-4939-3753-0_10.

Höfer J, Akbor M, Handle F, Ofer P, Puhr M, Parson W, Culig Z, Klocker H, Heidegger I
Critical role of androgen receptor level in prostate cancer cell resistance to new generation antiandrogen enzalutamide.
Oncotarget. 2016 Sep 13;7(37):59781-59794. doi: 10.18632/oncotarget.10926.

Willi M, Yoo KH, Wang C, Trajanoski Z, Hennighausen L.
Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation
Nucleic Acids Res. 2016 Dec 1;44(21):10277-10291.

Alonso Y Adell M, Migliano S, Teis D
ESCRT-III and Vps4: a dynamic multipurpose tool for membrane budding and scission
FEBS J. 2016 Sep;283(18):3288-302. doi: 10.1111/febs.13688. Review.

Curwin A, Brouwers N, Alonso Y Adell M, Teis D, Turacchio G, Parashuraman S, Ronchi P, Malhotra V
ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion
Elife. 2016 Apr 26;5. pii: e16299. doi: 10.7554/eLife.16299.

Flucher B, Tuluc P
How and why are calcium currents curtailed in the skeletal muscle voltage-gated calcium channels?
J Physiol. 2016 Nov 29. doi: 10.1113/JP273423. [Epub ahead of print]

Sebald J, Willi M, Schoberleitner I, Krogsdam A, Orth-Höller D, Trajanoski Z, Lusser A
Impact of the Chromatin Remodeling Factor CHD1 on Gut Microbiome Composition of Drosophila melanogaster
PLoS One. 2016 Apr 19;11(4):e0153476. doi: 10.1371/journal.pone.0153476. eCollection 2016.

Tuzlak S, Kaufmann T, Villunger A.
Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis
Genes Dev. 2016 Oct 1;30(19):2133-2151. Review.

Tuzlak S, Kaufmann T, Villunger A
Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis.
Genes Dev. 2016 Oct 1;30(19):2133-2151. Review. PubMed PMID: 27798841; PubMed Central PMCID: PMC5088

Pichler R, Gruenbacher G, Culig Z, Brunner A, Fuchs D, Fritz J, Gander H, Rahm A, Thurnher M
Intratumoral Th2 predisposition combines with an increased Th1 functional phenotype in clinical response to intravesical BCG in bladder cancer.
Cancer Immunol Immunother. 2016 Dec 22. doi: 10.1007/s00262-016-1945-z. [Epub ahead of print]

Sakamoto K, Wehde B, Yoo K, Kim T, Rajbhandari N, Shin H, Triplett A, Rädler P, Schuler F, Villunger A, Kang K, Hennighausen L, Wagner K
Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling
Mol Cell Biol. 2016 May 16;36(11):1673-90. doi: 10.1128/MCB.00999-15. PubMed PMID: 27044867; PubMed

Benedetti B, Benedetti A, Flucher B
Loss of the calcium channel β4 subunit impairs parallel fibre volley and Purkinje cell firing in cerebellum of adult ataxic mice
Eur J Neurosci. 2016 Jun;43(11):1486-98. doi: 10.1111/ejn.13241. Epub 2016 Apr 18

Knackmuss U, Lindner S, Aneichyk T, Kotkamp B, Knust Z, Villunger A, Herzog S
MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells.
Cell Death Differ. 2016 Feb;23(2):242-52.

Sochalska M, Schuler F, Weiss J, Prchal-Murphy M, Sexl V, Villunger A
MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis
Oncogene. 2016 Oct 3. doi: 10.1038/onc.2016.362. [Epub ahead of print] PubMed PMID: 27694901

Haller M, Khalid S, Kremser L, Fresser F, Furlan T, Hermann M, Guenther J, Drasche A, Leitges M, Giorgio M, Baier G, Lindner H, Troppmair J
Novel insights into the PKCβ-dependent regulation of the oxidoreductase p66Shc.
J Biol Chem. 2016 Sep 13. pii: jbc.M116.752766. [Epub ahead of print] PubMed PMID: 27624939.

Siegmund K, Klepsch-Pedit V, Hermann-Kleiter N, Baier G
Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.
J Biol Chem. 2016 Oct 14;291(42):22086-22092. Epub 2016 Aug 26.

Pfeifhofer-Obermair C, Albrecht-Schgör K, Peer S, Nairz M, Siegmund K, Klepsch-Pedit V, Haschka D, Thuille N, Hermann-Kleiter N, Gruber T, Weiss G, Baier G
Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice.
Cell Commun Signal. 2016 Jul 28;14(1):14

Handle F, Erb H, Luef B, Höfer J, Dietrich D, Parson W, Kristiansen G, Santer F, Culig Z
SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells.
Mol Cancer Res. 2016 Jun;14(6):574-85. doi: 10.1158/1541-7786.MCR-15-0495. Epub 2016 Apr 6.

Stanika R, Campiglio M, Pinggera A, Lee A, Striessnig J, Flucher B, Obermair G
Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology
Sci Rep. 2016 Oct 6;6:34528. doi: 10.1038/srep34528

Luef B, Handle F, Kharaishvili G, Hager M, Rainer J, Janetschek G, Hruby S, Englberger C, Bouchal J, Santer F, Culig Z
The AR/NCOA1 axis regulates prostate cancer migration by involvement of PRKD1.
Endocr Relat Cancer. 2016 Jun;23(6):495-508. doi: 10.1530/ERC-16-0160. Epub 2016 Jun 2.

Schrötter K, Dayal A, Grabner M
The mammalian skeletal muscle DHPR has larger Ca2+ conductance and is phylogenetically ancient to the early ray-finned fish sterlet (Acipenser ruthenus).
Cell Calcium. 2016 Oct 23. pii: S0143-4160(16)30163-4. doi: 10.1016/j.ceca.2016.10.002. [Epub ahead

Naschberger A, Fürnrohr B, Lenac Rovis T, Malic S, Scheffzek K, Dieplinger H, Rupp B
The N14 anti-afamin antibody Fab: a rare VL1 CDR glycosylation, crystallographic re-sequencing, molecular plasticity and conservative versus enthusiastic modelling
Acta Crystallogr D Struct Biol. 2016 Dec 1;72(Pt 12):1267-1280.

Dunzendorfer-Matt T, Mercado E, Maly K, McCormick F, Scheffzek K
The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation
Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7497-502. doi: 10.1073/pnas.1607298113.

Lammirato A, Patsch K, Feiereisen F, Maly K, Nofziger C, Paulmichl M, Hackl H, Trajanoski Z, Valovka T, Huber L, Vietor I
TIS7 induces transcriptional cascade of methylosome components required for muscle differentiation
BMC Biol. 2016 Oct 25;14(1):95.

Pichler R, Fritz J, Zavadil C, Schäfer G, Culig Z, Brunner A
Tumor-infiltrating immune cell subpopulations influence the oncologic outcome after intravesical Bacillus Calmette-Guérin therapy in bladder cancer.
Oncotarget. 2016 Jun 28;7(26):39916-39930. doi: 10.18632/oncotarget.9537.

Tuluc P, Benedetti B, Costé de Bagneaux P, Grabner M, Flucher B
Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in CaV1.1 calcium channels.
J Gen Physiol. 2016 Jun;147(6):437-49.

Kaur G, Pinggera A, Ortner N, Lieb A, Sinnegger-Brauns M, Yarov-Yarovoy V, Obermair G, Flucher B, Striessnig J
A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-Gated Cav1.2 Calcium Channel Function.
J Biol Chem. 2015 Aug 21;290(34):21086-100.

Fava L, Rainer J, Haschka M, Geley S, Villunger A
Beclin 1 is dispensable for chromosome congression and proper outer kinetochore assembly.
EMBO Rep. 2015 Oct;16(10):1233-6. doi: 10.15252/embr.201540731. Epub 2015 Aug 20.

Ofer P, Heidegger I, Eder I, Schöpf B, Neuwirt H, Geley S, Klocker H, Massoner P
Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo.
Mol Endocrinol. 2015 Dec;29(12):1694-707. doi: 10.1210/me.2015-1073. Epub 2015 Oct 9.

Pinggera A, Lieb A, Benedetti B, Lampert M, Monteleone S, Liedl K, Tuluc P, Striessnig J
CACNA1D de novo mutations in autism spectrum disorders activate Cav1.3 L-type calcium channels.
Biol Psychiatry. 2015 May 1;77(9):816-22.

Angelova M, Charoentong P, Hackl H, Fischer M, Snajder R, Krogsdam A, Waldner M, Bindea G, Mlecnik B, Galon J, Trajanoski Z
Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
Genome Biol. 2015 Mar 31;16(1):64.

Naschberger A, Fürnrohr BG, Dunzendorfer-Matt T, Bonagura CA, Wright D, Scheffzek K, Rupp B
Cleaning protocols for crystallization robots: preventing protease contamination.
Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):100-2. doi: 10.1107/S2053230X14026053.

Wöss C, Tuzlak S, Labi V, Drach M, Bertele D, Schneider P, Villunger A
Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice.
Cell Death Differ. 2015.

Amort M, Nachbauer B, Tuzlak S, Kieser A, Schepers A, Villunger A, Polacek N
Expression of the vault RNA protects cells from undergoing apoptosis.
Nat Commun. 2015 May 8;6:7030.

Mairhofer D, Ortner D, Tripp C, Schaffenrath S, Fleming V, Heger L, Komenda K, Reider D, Dudziak D, Chen S, Becker J, Flacher V, Stoitzner P
Impaired gp100-Specific CD8+ T Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model.
J Invest Dermatol. 2015 Jun 29.

Mlecnik B, Bindea G, Angell HK, Maby P, Angelova M, Tougeron D, Church SE, Lafontaine L, Fischer M, Fredriksen T, Sasso M, Bilocq AM, Kirilovsky A, Obenauf AC, Hamieh M, Berger A, Bruneval P, Tuech J, Sabourin J, Le Pessot F, Mauillon J, Rafii A, Laurent-Puig P, Speicher M, Trajanoski Z, Michel P, Sesboüe R, Frebourg T, Pagès F, Valge-Archer V, Latouche J, Galon J
Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability
Immunity. 2016 Mar 15;44(3):698-711. doi: 10.1016/j.immuni.2016.02.025.

Heidegger I, Höfer J, Luger M, Pichler R, Klocker H, Horninger W, Steiner E, Jochberger S, Culig Z
Is Eotaxin-1 a serum and urinary biomarker for prostate cancer detection and recurrence?
Prostate. 2015 Dec;75(16):1904-9. doi: 10.1002/pros.23086. Epub 2015 Aug 26.

Ottina E, Lyberg K, Sochalska M, Villunger A, Nilsson G
Knockdown of the antiapoptotic Bcl-2 family member A1/Bfl-1 protects mice from anaphylaxis.
J Immunol. 2015 Feb 1;194(3):1316-22.

Ortner N, Striessnig J
L-type calcium channels as drug targets in CNS disorders.
Channels (Austin). 2016;10(1):7-13.

Sochalska M, Tuzlak S, Egle A, Villunger A
Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.
FEBS J. 2015 Mar;282(5):834-49.

Pichler R, Borena W, Schäfer G, Manzl C, Culig Z, List S, Neururer S, Von Laer D, Heidegger I, Klocker H, Horninger W, Steiner H, Brunner A
Low prevalence of HPV detection and genotyping in non-muscle invasive bladder cancer using single-step PCR followed by reverse line blot.
World J Urol. 2015 Dec;33(12):2145-51. doi: 10.1007/s00345-015-1539-y. Epub 2015 Mar 19.

Santer F, Erb H, Oh S, Handle F, Feiersinger G, Luef B, Bu H, Schäfer G, Ploner C, Egger M, Rane J, Maitland N, Klocker H, Eder I, Culig Z
Mechanistic rationale for Mcl1 inhibition during androgen deprivation therapy
Oncotarget. 2015 Mar 20;6(8):6105-22.

Pasqualini L, Bu H, Puhr M, Narisu N, Rainer J, Schlick B, Schäfer G, Angelova M, Trajanoski Z, Börno S, Schweiger M, Fuchsberger C, Klocker H
miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer.
Mol Endocrinol. 2015 Jul;29(7):1037-54.

Striessnig J, Ortner N, Pinggera A
Pharmacology of L-type calcium channels: novel drugs for old targets?
Curr Mol Pharmacol. 2015;8(2):110-22.

Benedetti B, Tuluc P, Mastrolia V, Dlaska C, Flucher B
Physiological and pharmacological modulation of the embryonic skeletal muscle calcium channel splice variant CaV1.1e.
Biophys J. 2015 Mar 10;108(5):1072-80.

Rebsamen M, Pochini L, Stasyk T, de Araújo M, Galluccio M, Kandasamy R, Snijder B, Fauster A, Rudashevskaya E, Bruckner M, Scorzoni S, Filipek P, Huber K, Bigenzahn J, Heinz L, Kraft C, Bennett K, Indiveri C, Huber L, Superti-Furga G
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.
Nature. 2015 Mar 26;519(7544):477-81

Vosper J, Masuccio A, Kullmann M, Ploner C, Geley S, Hengst L
Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation
Oncotarget. 2015 Feb 20;6(5):2889-902

Ottina E, Sochalska M, Sgonc R, Villunger A
The BH3-only protein Bad is dispensable for TNF-mediated cell death.
Cell Death Dis. 2015 Jan 22;6:e1611.

Schuler F, Baumgartner F, Klepsch-Pedit V, Chamson M, Müller-Holzner E, Watson C, Oh S, Hennighausen L, Tymoszuk P, Doppler W, Villunger A
The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.
Cell Death Differ. 2015 Jun 5. doi: 10.1038/cdd.2015.61. [Epub ahead of print]

Müller M, Schmidt O, Angelova M, Faserl K, Weys S, Kremser L, Pfaffenwimmer T, Dalik T, Kraft C, Trajanoski Z, Lindner H, Teis D
The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation.
Elife. 2015 Apr 22;4:e07736.

Haschka M, Soratroi C, Kirschnek S, Häcker G, Hilbe R, Geley S, Villunger A, Fava L
The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrest.
Nat Commun. 2015 Apr 29;6:6891.

Hermann-Kleiter N, Klepsch-Pedit V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, Villunger A, Kaminski S, Pfeifhofer-Obermair C, Gruber T, Wolf D, Baier G
The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Cell Rep. 2015 Sep 29;12(12):2072-85.

Peintner L, Dorstyn L, Kumar S, Aneichyk T, Villunger A, Manzl C
The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.
Cell Death Differ. 2015 Apr 10, 1-9.

Vogel G, Ebner H, de Araujo M, Schmiedinger T, Eiter O, Pircher H, Gutleben K, Witting B, Teis D, Huber L, Hess M
Ultrastructural Morphometry Points to a New Role for LAMTOR2 in Regulating the Endo/Lysosomal System
Traffic. 2015 Jun;16(6):617-34. doi: 10.1111/tra.12271.